We are a lean, virtual institute empowered by the NASA Human Research Program to solve the challenges of human deep space exploration. We relentlessly seek and support high-impact science and technologies to enable every human to explore Mars safely. We find and fund disruptive, breakthrough approaches that reduce risks to human health and performance. TRISH supports both high-risk early-stage research as well as pre-seed and seed-stage health technologies that can be modified for use by astronauts on the way to Mars. Led by Baylor College of Medicine's Center for Space Medicine, our consortium leverages partnerships with Caltech and MIT.