SMi’s automated, high resolution optical technology is capable of viewing single-molecule interactions in real time. It is the first optical technology to achieve such a high spatial (1.6 nm) and temporal (500 µs) resolution. Using this significant advancement in optical technology, SMi is developing a range of intelligent instruments including: - A diagnostic platform capable of targeting a wide range of clinical challenges such as infectious disease and antimicrobial resistance. We are currently developing our device to rapidly detect COVID in patients who are infected within the first 24 hours of infection. This high performance device can process up to 1000 patient samples in less than 20 minutes, a capacity of 72000 samples, per day, per device. - A microscope that allows scientists to directly observe the kinetics of individual molecular interactions in real-time and at a resolution close to that seen in crystallography. This allows scientists to determine key components of single drug-receptor interactions, such as their number, positions, and rate constants. For diagnosis SMi’s devices provide irrefutable evidence for the presence of infectious agents. For drug discovery it is the first time that scientists have been able to directly monitor the binding of drugs to their targets.