Enel Foundation is a non-profit organization focusing on the crucial role of clean energy to ensure a sustainable future for all. By developing partnerships with pre-eminent experts and institution across the globe, leveraging on the vast knowledge of its Founders, Enel Foundation conducts research to explore the implications of global challenges in the energy domain and offers education programs to the benefit of talents in the scientific, business and institutional realms. Our analysis covers four major areas that are shaping the evolution of the energy sector, to different degrees, all over the world. We look at the way in which technology is creating new possibilities for energy production, storage, distribution, management and usage, and consequently at how policy and regulation dimensions need to evolve to adjust and adapt to the new possibilities. We also explore how human and natural capital is accelerating or shaping the energy transition process, especially in areas of the world mostly exposed to the challenges of climate change. In addition, we focus on the different ways in which geographies cope with the global megatrends and achieve their transition towards a clean energy future.