JAMA, published continuously since 1883, is an international peer-reviewed general medical journal. JAMA is a member of the JAMA Network family of journals, which includes 10 specialty journals, JAMA Health Forum and JAMA Network Open. JAMA is the most widely circulated medical journal in the world, with more than 320,000 recipients of the print journal, 1.2 million recipients of electronic tables of contents and alerts, and over 20 million annual visits to the journal's website. JAMA's reach includes a growing social media presence and vast international news media exposure, including 6-8 million viewers of the JAMA video news report each week. JAMA is published 48 times per year in print/online issues, and new articles are published several times a week online. Without any author fees, all research articles are made free access online 6 months after publication on the JAMA website. In addition, the online version is freely available or nearly so to institutions in developing countries through the World Health Organization's HINARI program. Kirsten Bibbins-Domingo, PhD, MD, MAS, is the Editor in Chief of JAMA, and Phil B. Fontanarosa, MD, MBA, is the Executive Editor. JAMA is a member of the International Committee of Medical Journal Editors, cosponsors the International Congress on Peer Review and Biomedical Publication, and is a member of the African Journal Partnership Project and is partnered with the Malawi Medical Journal. JAMA's key objective is to promote the science and art of medicine and the betterment of the public health ISSN 0098-7484 (Print) ISSN 1538-3598 (Online)