BrainPlotting is a french contract research organization company which offers his knowledge to predict the entrance of drugs into the brain To that end BrainPlotting developped in vitro models based on fresh human tissus and cells. BrainPlotting is incubated at the Brain and Spine Institute (ICM), Paris, France Our core business is the study of pharmacokinetics (PK) in the human brain. The molecules that we study can have CNS targets as well as peripheral targets. To study the brain's PK, BrainPlotting uses the most accurate predictive models and the most recent methods and tools. To generate the highest-accuracy predictive models, BrainPlotting developed proprietary in vitro models based on primary human cells. PK predictions can be made at various stages of the molecules' development (e.g. screening, Hit-to-Lead, lead optimization) by using a variety of methods, such as: · Evaluation of the blood-brain barrier permeability from absorption (blood to brain) to elimination (brain to blood) · Determination of the unbound fraction of the drug in the blood and in the brain · Estimation of the drug concentration in the brain in both ECF and ICF in fresh human brain slices · Modeling the human in vivo concentration based on human in vitro data